Revista do Colégio Brasileiro de Cirurgiões
https://revistadocbc.org.br/article/doi/10.1590/0100-6991e-2026002626
Revista do Colégio Brasileiro de Cirurgiões
Artigo de Revisão

Estratificação do risco cardíaco perioperatório: a avaliação da capacidade funcional é capaz de predizer complicações perioperatórias, incluindo óbito?

Perioperative cardiac risk stratification: is functional capacity assessment able to predict perioperative complications, including death?

Gabriela Chaves Lucas; Soraya Anita Mendes Sá; Thyago Araújo Fernandes; José Carlos Rodrigues Nascimento; Nuno Domingos Garrido; Victor Reis Machado; José Manuel Vilaça Alves

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Resumo

Introdução: A triagem de risco perioperatório visa otimizar a tomada de decisão clínica por meio da identificação do risco cardíaco em pacientes submetidos a cirurgias não cardíacas. As diretrizes atuais de organizações como a European Society of Cardiology (ESC) e Sociedade Brasileira de Cardiologia (SBC) incorporam avaliações subjetivas da capacidade funcional, frequentemente utilizando o limiar de 4 METs como marcador de baixa capacidade funcional. Apesar das atualizações recentes dessas diretrizes, a literatura permanece conflitante, e o poder preditivo das ferramentas subjetivas para desfechos perioperatórios é incerto.

Métodos: Conduzimos uma revisão sistemática, em conformidade com as diretrizes PRISMA, sobre a eficácia de ferramentas de avaliação subjetiva da capacidade funcional quanto ao seu poder preditivo para complicações cardíacas perioperatórias, incluindo morte. Foram pesquisadas quatro bases de dados: PUBMED, SCOPUS, WOS e Science Direct.

Resultados: Os resultados indicam que a capacidade autorreferida de subir dois lances de escadas, embora demonstre poder associativo, frequentemente não melhora o poder preditivo dos modelos de risco. Em contraste, ferramentas de avaliação mais abrangentes com dados contínuos, como o Duke Activity Status Index (DASI) e os níveis semanais de atividade física, parecem ser mais promissoras.

Conclusões: Esses resultados sugerem que as diretrizes atuais de estratificação de risco perioperatório necessitam de reavaliação crítica no que se refere à inclusão da capacidade funcional subjetiva. É de suma importância distinguir de forma eficaz o poder associativo da avaliação subjetiva da capacidade funcional de seu poder preditivo, quando comparado às informações já obtidas do paciente.

Palavras-chave

Risco Cardíaco Perioperatório; Avaliação da Capacidade Funcional; Perioperatório; MACE

Abstract

Introduction: Perioperative risk screening seeks to optimize medical decision-making by identifying cardiac risk in patients undergoing noncardiac surgery. The current guidelines of organizations such as the European Society of Cardiology (ESC) and the Brazilian Society of Cardiology (SBC)incorporate assessments of subjective functional capacity, often using the threshold of 4 METs as a marker of low functional capacity. Despite recent updates to these guidelines, the literature remains conflicting, and the predictive power of subjective tools for perioperative outcomes is uncertain.

Methods: We conducted a systematic review, in accordance with PRISMA guidelines, on the effectiveness of subjective functional capacity assessment tools regarding their predictive power for perioperative cardiac complications, including death. Four databases were searched: PUBMED, SCOPUS, WOS, and Science Direct.

Results: The results indicate that the self-reported ability to climb two flights of stairs, although demonstrating associative power, often did not improve the predictive power of risk models. In contrast, more comprehensive assessment tools with continuous data, such as the Duke Activity Status Index (DASI) and weekly levels of physical activity, appear to be more promising.

Conclusion: These results suggest that current perioperative risk stratification guidelines need to be critically re-evaluated with regard to the inclusion of subjective functional capacity. It is of paramount importance to effectively distinguish the associative power of the subjective assessment of functional capacity from its predictive power when compared with information already obtained from the patient.

Keywords

Perioperative Cardiac Risk; Functional Capacity Assessment; Perioperative; MACE

Referências

1 Chopra V, Flanders SA, Froehlich JB, Lau WC, Eagle KA. Perioperative practice: time to throttle back. Ann Intern Med. 2010;152(1):47-51. doi:10.7326/0003-4819-152-1-201001050-00184

2 Olsen DM, Kane RL, Proctor PH. A controlled trial of multiphasic screening. N Engl J Med. 1976;294(17):925-30. doi:10.1056/NEJM197604222941705

3 Wyatt WJ, Reed DN Jr, Apelgren KN. Pitfalls in the role of standardized preadmission screening for ambulatory surgery. Surv Anesthesiol. 1990;34(3):167.

4 Fleisher LA. Preoperative evaluation in 2020: does exercise capacity fit into decision-making? Br J Anaesth. 2020;125(3):224-6. doi:10.1016/j.bja.2020.05.053

5 Gualandro DM, Fornari LS, Caramelli B, Abizaid AAC, Gomes BR, Tavares CAM, et al. Guideline for perioperative cardiovascular evaluation of the Brazilian Society of Cardiology - 2024. Arq Bras Cardiol. 2024;121(9):e20240590. doi:10.36660/abc.20240590

6 Halvorsen S, Mehilli J, Cassese S, Hall TS, Abdelhamid M, Barbato E, et al. 2022 ESC Guidelines on cardiovascular assessment and management of patients undergoing non-cardiac surgery. Eur Heart J. 2022;43(39):3826-3924. doi:10.1093/eurheartj/ehac270

7 Thompson A, Fleischmann KE, Smilowitz NR, de Las Fuentes L, Mukherjee D, Aggarwal NR, et al. 2024 AHA/ACC/ACS/ASNC/HRS/SCA/SCCT/SCMR/SVM Guideline for Perioperative Cardiovascular Management for Noncardiac Surgery: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2024;150(19):e351-e442. https://doi.org/10.1161/CIR.0000000000001285

8 Smilowitz NR, Berger JS. Perioperative cardiovascular risk assessment and management for noncardiac surgery: a review. JAMA. 2020;324(3):279-290. doi:10.1001/jama.2020.7840

9 Fleisher LA, Fleischmann KE, Auerbach AD, Barnason SA, Beckman JA, Bozkurt B, et al. 2014 ACC/AHA guideline on perioperative cardiovascular evaluation and management of patients undergoing noncardiac surgery: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation. 2014;130(24):2215-45. doi:10.1161/CIR.0000000000000105

10 Gualandro D, Yu P, Marques A, Calderaro D, Fornari L. 3ª Diretriz de Avaliação Cardiovascular Perioperatória da Sociedade Brasileira de Cardiologia. Arq. Bras. Cardiol. 2017; 109(3 suppl 1): 1-104. doi: 10.5935/abc.20170140.

11 Papanicolas I, Woskie LR, Jha AK. Health care spending in the United States and other high-income countries. JAMA. 2018;319(10):1024-1039. doi:10.1001/jama.2018.1150

12 Wijeysundera DN, Pearse RM, Shulman MA, Abbott TEF, Torres E, Ambosta A, et al. Assessment of functional capacity before major non-cardiac surgery: an international, prospective cohort study. Lancet. 2018;391(10140):2631-2640. doi:10.1016/S0140-6736(18)31131-0

13 Buse GL, Mauermann E, Ionescu D, Szczeklik W, De Hert S, Filipovic M, et al. Risk assessment for major adverse cardiovascular events after noncardiac surgery using self-reported functional capacity: international prospective cohort study. Br J Anaesth. 2023;130(6):655-665. https://doi.org/10.1016/j.bja.2023.02.030.

14 Visseren FLJ, Mach F, Smulders YM, Carballo D, Koskinas KC, Bäck M, et al. 2021 ESC guidelines on cardiovascular disease prevention in clinical practice. Eur Heart J. 2021;42(34):3227-3337. doi:10.1093/eurheartj/ehab484

15 PRISMA 2020 explanation and elaboration: updated guidance and exemplars for reporting systematic reviews. BMJ. 29 de março de 2021;372:n160. doi:10.1136/bmj.n160 PubMed PMID: 33781993.

16 Fernandez-Felix BM, López-Alcalde J, Roqué M, Muriel A, Zamora J. CHARMS and PROBAST at your fingertips: a template for data extraction and risk of bias assessment in systematic reviews of predictive models. BMC Med Res Methodol. 2023;23(1):44. doi:10.1186/s12874-023-01849-0

17 GRADE Working Group. GRADE handbook for grading the certainty of evidence and strength of recommendations. Available from: https://gdt.gradepro.org/app/handbook/handbook.html

18 Buse GL, Puelacher C, Gualandro DM, Genini AS, Hidvegi R, Bolliger D, et al. Association between self-reported functional capacity and major adverse cardiac events in patients at elevated risk undergoing noncardiac surgery: a prospective diagnostic cohort study. Br J Anaesth. 2021;126(1):102-110. https://doi.org/10.1016/j.bja.2020.08.041

19 Buse GL, Larmann J, Gillmann HJ, Kotfis K, Ganter MT, Bolliger D, et al. NT-proBNP or self-reported functional capacity in estimating risk of cardiovascular events after noncardiac surgery. JAMA Netw Open. 2023;6(11):e2342527. doi:10.1001/jamanetworkopen.2023.42527

20 Shah AC, Ma K, Faraoni D, Oh DCS, Rooke GA, Van Norman GA. Self-reported functional status predicts post-operative outcomes in non-cardiac surgery patients with pulmonary hypertension. PLoS One. 2018;13(8):e0201914. doi:10.1371/journal.pone.0201914

21 Reilly DF, McNeely MJ, Doerner D, Greenberg DL, Staiger TO, Geist MJ, et al. Self-reported exercise tolerance and the risk of serious perioperative complications. Arch Intern Med. 1999;159(18):2185-2192. doi:10.1001/archinte.159.18.2185

22 Deo AS, Kashyapi R, Joshi V, Balakundi P, Raman P, et al. Predictors of peri-operative cardiac events and development of a scoring tool for patients with chronic kidney disease undergoing non-cardiac surgeries: a prospective observational multicentre study. Indian J Anaesth. 2022;66(4):278-289. doi:10.4103/ija.ija_1031_2

23 Marsman M, van Waes JAR, Grobben RB, Weersink CSA, van Klei WA. Added value of subjective assessed functional capacity before non-cardiac surgery in predicting postoperative myocardial injury. Eur J Prev Cardiol. 2021;28(3):262-269. doi:10.1177/2047487320906918

24 Wiklund RA, Stein HD, Rosenbaum SH. Activities of daily living and cardiovascular complications following elective, noncardiac surgery. Yale J Biol Med. 2001;74(2):75-87.

25 Kaw R, Nagarajan V, Jaikumar L, Halkar M, Mohananey D, Hernandez AV, et al. Predictive value of stress testing, revised cardiac risk index, and functional status in patients undergoing noncardiac surgery. J Cardiothorac Vasc Anesth. 2019;33(4):927-932. doi:10.1053/j.jvca.2018.07.020

26 Hlatky MA, Boineau RE, Higginbotham MB, Lee KL, Mark DB, Califf RM, et al. A brief self-administered questionnaire to determine functional capacity (the Duke Activity Status Index). Am J Cardiol. 1989;64(10):651-654. doi:10.1016/0002-9149(89)90496-7

27 Tsiouris A, Horst HM, Paone G, Hodari A, Eichenhorn M, Rubinfeld I. Preoperative risk stratification for thoracic surgery using the American College of Surgeons National Surgical Quality Improvement Program data set: functional status predicts morbidity and mortality. J Surg Res. 2012;177(1):1-6. doi:10.1016/j.jss.2012.02.048

28 Wijeysundera DN, Beattie WS, Hillis GS, Abbott TEF, Shulman MA, Ackland GL, et al. Integration of the Duke Activity Status Index into preoperative risk evaluation: a multicentre prospective cohort study. Br J Anaesth. 2020;124(3):261-270. doi:10.1016/j.bja.2019.11.025

29 Duceppe E, Parlow J, MacDonald P, Lyons K, McMullen M, Srinathan S, et al. Canadian Cardiovascular Society Guidelines on Perioperative Cardiac Risk Assessment and Management for Patients Who Undergo Noncardiac Surgery. Can J Cardiol. 2017;33(1):17-32. doi:10.1016/j.cjca.2016.09.008

30 Duceppe E, Patel A, Chan MTV, Berwanger O, Ackland G, Kavsak PA, et al. Preoperative N-Terminal Pro-B-Type Natriuretic Peptide and Cardiovascular Events After Noncardiac Surgery: A Cohort Study. Ann Intern Med. 2020;172(2):96-104. doi:10.7326/M19-2501

31 Esmati S, Tavoosi A, Mehrban S, Laleh Far V, Mehrakizadeh A, Shahi S, et al. NT-proBNP level as a substitute for myocardial perfusion scan in preoperative cardiovascular risk assessment in noncardiac surgery. BMC Anesthesiol. 2023;23(1):244. https://doi.org/10.1186/s12871-023-02205-x.
 

 

Submetido em:
02/03/2026

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24/04/2026

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